{"subject":"榮譽副院長/國際事務策略長","pubUnitName":"生命科學院","posterDate":"115-05-14","updateDate":"115-05-14","detailContent":"<div class=\"ed_model03 clearfix\">\r\n<div class=\"ed_pic_left\"><img alt=\"榮譽副院長\" src=\"/userfiles/clsch/images/20260512145443522.jpg\"></div>\r\n\r\n<div class=\"ed_title01\">黃雪莉榮譽副院長/國際事務策略長</div>\r\n\r\n<div class=\"ed_txt\">sl.huang@nycu.edu.tw<br>\r\n#67108</div>\r\n</div><div class=\"ed_model18 clearfix\"><button aria-controls=\"ed_model18_collapse6484601\" aria-expanded=\"false\" class=\"btn w-100 text-start d-flex justify-content-between\" data-bs-target=\"#ed_model18_collapse6484601\" data-bs-toggle=\"collapse\" type=\"button\">\r\n<div class=\"ed-model18-title-text\">職責</div>\r\n\r\n<div class=\"arrow\">\r\n<div> </div>\r\n</div>\r\n</button>\r\n\r\n<div class=\"collapse show\" id=\"ed_model18_collapse6484601\">\r\n<div class=\"content\">\r\n<div>國際學程洽談代表</div>\r\n</div>\r\n</div>\r\n<button aria-controls=\"ed_model18_collapse6484602\" aria-expanded=\"false\" class=\"btn w-100 text-start d-flex justify-content-between\" data-bs-target=\"#ed_model18_collapse6484602\" data-bs-toggle=\"collapse\" type=\"button\">\r\n<div class=\"ed-model18-title-text\">現任</div>\r\n\r\n<div class=\"arrow\">\r\n<div> </div>\r\n</div>\r\n</button>\r\n\r\n<div class=\"collapse show\" id=\"ed_model18_collapse6484602\">\r\n<div class=\"content\">\r\n<div>國立陽明交通大學微生物及免疫學研究所 教授</div>\r\n</div>\r\n</div>\r\n<button aria-controls=\"ed_model18_collapse6484603\" aria-expanded=\"false\" class=\"btn w-100 text-start d-flex justify-content-between\" data-bs-target=\"#ed_model18_collapse6484603\" data-bs-toggle=\"collapse\" type=\"button\">\r\n<div class=\"ed-model18-title-text\">簡要經歷</div>\r\n\r\n<div class=\"arrow\">\r\n<div> </div>\r\n</div>\r\n</button>\r\n\r\n<div class=\"collapse show\" id=\"ed_model18_collapse6484603\">\r\n<div class=\"content\">\r\n<div>國立陽明交通大學 國際事務處 國際長 <br>\r\n國立陽明大學 國際事務處 國際長 <br>\r\n國際原核生物系統分類學委員會台灣代表<br>\r\n國立陽明大學 微生物及免疫學研究所 所長 <br>\r\n國立陽明大學 醫學院 微生物學科 科主任 <br>\r\n美國微生物學會台灣大使<br>\r\n台灣微生物生態學學會 理事長<br>\r\n亞洲微生物生態學研討會 女科學家圓桌 台灣代表</div>\r\n</div>\r\n</div>\r\n</div><div class=\"ed_model18 clearfix\"><button aria-controls=\"ed_model18_collapse55563951\" aria-expanded=\"false\" class=\"btn w-100 text-start d-flex justify-content-between\" data-bs-target=\"#ed_model18_collapse55563951\" data-bs-toggle=\"collapse\" type=\"button\">\r\n<div class=\"ed-model18-title-text\">專業領域</div>\r\n\r\n<div class=\"arrow\">\r\n<div> </div>\r\n</div>\r\n</button>\r\n\r\n<div class=\"collapse show\" id=\"ed_model18_collapse55563951\">\r\n<div class=\"content\">\r\n<div>細菌生化、細菌生理、蛋白質體學、藥物研發</div>\r\n</div>\r\n</div>\r\n<button aria-controls=\"ed_model18_collapse55563952\" aria-expanded=\"false\" class=\"btn w-100 text-start d-flex justify-content-between\" data-bs-target=\"#ed_model18_collapse55563952\" data-bs-toggle=\"collapse\" type=\"button\">\r\n<div class=\"ed-model18-title-text\">研究方向</div>\r\n\r\n<div class=\"arrow\">\r\n<div> </div>\r\n</div>\r\n</button>\r\n\r\n<div class=\"collapse show\" id=\"ed_model18_collapse55563952\">\r\n<div class=\"content\">\r\n<div>(I)人體厭氧共生菌的代謝及與其他菌之互利共生作用<br>\r\n微生物在自然環境中通常以多物種群落形式存在，這樣的互動生態系統涵蓋了代謝交叉餵養和群體感應等過程。傳統益生菌乳酸菌在腸道中產生大量的乳酸，而人體內過多的乳酸堆積與關節炎與許多疾病相關。口腔和腸道中的乳酸利用菌能利用乳酸並產生有益代謝物短鏈脂肪酸，在腸道乳酸平衡中扮演重要角色協助維持腸道生態恆定。我們的研究發現常見的乳酸產生菌lactobacilli與乳酸利用菌Veillonella dispar之間具有互利共生關係，lactobacilli不但交叉餵養乳酸、並發現亦提供谷氨酸給V. dispar因而顯著 地促進兩菌株的生長、活性和短鏈脂肪酸的產生利用共培養菌體之轉錄體、代謝體等方法在基礎研究上闡明了傳統乳酸益生菌與乳酸利用菌之間複雜的代謝關係，並提出乳酸產生 /利用菌之間的相互作用對維持腸道乳酸平衡的重要，我們的研究亦提供新型益生菌產品開發的新方向。<br>\r\n<img alt=\"研究一\" src=\"/userfiles/clsch/images/20260514155349899.png\"><br>\r\nPublication:<br>\r\n1. Zhang, S. M., & Huang, S. L. (2023). The commensal anaerobe Veillonella dispar reprograms its lactate metabolism and short-chain fatty acid production during the stationary phase. Microbiology spectrum, 11(2), e03558-22.<br>\r\n2. Zhang, S. M., Hung, J. H., Yen, T. N., & Huang, S. L. (2024). Mutualistic interactions of lactate‐producing lactobacilli and lactate‐utilizing Veillonella dispar: Lactate and glutamate cross‐feeding for the enhanced growth and short‐chain fatty acid production. Microbial Biotechnology, 17(5), e14484.<br>\r\n3. Hung, J. H., Zhang, S. M. & Huang, S. L. (2024). Nitrate promotes the growth and the productions of short-chain fatty acids and tryptophan from commensal anaerobe Veillonella dispar in the lactate-deficient environment by facilitating the catabolism of glutamate and aspartate. Applied and Environmental Microbiology (in revision).<br>\r\n<br>\r\n(II) 環境荷爾蒙之微生物降解<br>\r\n<img alt=\"研究二\" src=\"/userfiles/clsch/images/20260514155349825.jpg\"><br>\r\n<br>\r\n(III) 乳化劑對腸道菌之作用<br>\r\n<img alt=\"研究三\" src=\"/userfiles/clsch/images/20260514155350026.jpg\"></div>\r\n</div>\r\n</div>\r\n</div>","languageUrl":null,"docs":[],"images":[],"videos":[],"audios":[],"resources":[]}